Finished another two problem sets today; Aromatic Synthesis 2 and Aromatic Synthesis 3. I learned a few tips and tricks and around five reagents that I came across in CHM242 but soon forgot.
Aromatic Synthesis 2 (Answers)
Aromatic Synthesis 3 (Answers)
Steer clear from Sulfonation and NaOH, as well as bromination followed by an organocuprate attack. They crop up a few times in these problem sets, and it's confusing because these are industrial techniques, meaning it's not something we're taught in class. Don't worry about questions involving these two.
In Aromatic Synthesis 3 you'll also come across some reagents like PBr3 and POCl3, for example. Take a quick look at Google Images for the mechanisms so you understand why they're being used. However, don't worry if you didn't think of using them right away - we're not exactly using them in class. It's best if you focus on doing the questions that you can complete using what we've been taught in class.
I think you mean SOCl2
ReplyDeleteThanks for pointing that out. I actually meant to write POCl3, which is used to create an alkene from an alcohol. It's useful because it saves a step, as you'd otherwise have to maybe tosylate the alcohol and add a strong bulky base to eliminate.
Deletenice
ReplyDelete